The title refers to Nicholas Flamel's wife Perenelle, who really comes into her own in this volume, which takes place largely in England, except the bits dealing with her escape - finally! - from Alcatraz, which seems not to be a tourist destination in this world. Josh loses his sword, Clarent, which Dee gets and unites it with his own sword, Excalibur, to create a new all-powerful weapon. Flamel and the twins meanwhile hook up with a Saracen named Palamedes which provides some military might.
More new characters are introduced, such as Gilgamesh of Epic fame, and meanwhile Niccolò Machiavelli teams up with Billy the kid of all people. That seems to be a serious mismatch. However, this story was also entertaining, so I commend it.